LMPD Database

LMP002749

Record overview

LMPD IDLMP002749
Gene ID8703
SpeciesHomo sapiens (Human)
Gene NameUDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
Gene SymbolB4GALT3
Synonymsbeta4Gal-T3
Chromosome1
Map Location1q21-q23
SummaryThis gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2010]
OrthologsView orthologs and multiple alignments for B4GALT3

Proteins

beta-1,4-galactosyltransferase 3
Refseq ID:NP_001186802
Protein GI:315467841
UniProt ID:O60512
mRNA ID:NM_001199873
Length:393
RefSeq Status:REVIEWED
MLRRLLERPCTLALLVGSQLAVMMYLSLGGFRSLSALFGRDQGPTFDYSHPRDVYSNLSHLPGAPGGPPAPQGLPYCPERSPLLVGPVSVSFSPVPSLAE
IVERNPRVEPGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLP
ENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEEN
PHRFDLLVRTQNSWTQDGMNSLTYQLLARELGPLYTNITADIGTDPRGPRAPSGPRYPPGSSQAFRQEMLQRRPPARPGPLSTANHTALRGSH
 
beta-1,4-galactosyltransferase 3
Refseq ID:NP_001186803
Protein GI:315467844
UniProt ID:O60512
mRNA ID:NM_001199874
Length:393
RefSeq Status:REVIEWED
Protein sequence is identical to GI:315467841 (mRNA isoform)
 
beta-1,4-galactosyltransferase 3
Refseq ID:NP_003770
Protein GI:4502349
UniProt ID:O60512
mRNA ID:NM_003779
Length:393
RefSeq Status:REVIEWED
Protein sequence is identical to GI:315467841 (mRNA isoform)