LMPD Database

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LMP002559

Record overview

LMPD IDLMP002559
Gene ID2880
SpeciesHomo sapiens (Human)
Gene Nameglutathione peroxidase 5
Gene SymbolGPX5
SynonymsHEL-S-75p
Alternate namesepididymal secretory glutathione peroxidase; EGLP; GPx-5; GSHPx-5; epididymal androgen-related protein; epididymis secretory sperm binding protein Li 75p; epididymis-specific glutathione peroxidase-like protein
Chromosome6
Map Location6p22.1
EC Number1.11.1.9
SummaryThis gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2008]
OrthologsView orthologs and multiple alignments for GPX5

Proteins

epididymal secretory glutathione peroxidase isoform 1 precursor
Refseq ID:NP_001500
Protein GI:4557629
UniProt ID:O75715
mRNA ID:NM_001509
Length:221
RefSeq Status:REVIEWED
MTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYVGKHILFVNVATYCGLTAQYPELNALQEELKPYGLVVLGFP
CNQFGKQEPGDNKEILPGLKYVRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLKHSCPHPSEILGTFKSISWDPVKVHDIRWNFEKFLVGPDGIPVMRWSH
RATVSSVKTDILAYLKQFKTK
 
epididymal secretory glutathione peroxidase isoform 2 precursor
Refseq ID:NP_003987
Protein GI:6715602
UniProt ID:O75715
mRNA ID:NM_003996
Length:100
RefSeq Status:REVIEWED
MTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYVGKHILFVNVATYCGLTAQYPGMSVQGEDLYLVSSFLRKGM
 
sig_peptide: 1..21
calculated_mol_wt: 2397
peptide sequence: 
MTTQLRVVHLLPLLLACFVQT

mat_peptide: 22..221
product: epididymal secretory glutathione peroxidase isoform 1
calculated_mol_wt: 22823
peptide sequence: 
SPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYVGKHILFVNVATYCGLTAQYPELNALQEELKPYGLVVLGFPCNQFGKQEPGDNKEILPGLKY
VRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLKHSCPHPSEILGTFKSISWDPVKVHDIRWNFEKFLVGPDGIPVMRWSHRATVSSVKTDILAYLKQFKTK


sig_peptide: 1..21
calculated_mol_wt: 2397
peptide sequence: 
MTTQLRVVHLLPLLLACFVQT

mat_peptide: 22..100
product: epididymal secretory glutathione peroxidase isoform 2
calculated_mol_wt: 9050
peptide sequence: 
SPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYVGKHILFVNVATYCGLTAQYPGMSVQGEDLYLVSSFLRKGM