LMPD Database

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LMP002513

Record overview

LMPD IDLMP002513
Gene ID53637
SpeciesHomo sapiens (Human)
Gene Namesphingosine-1-phosphate receptor 5
Gene SymbolS1PR5
SynonymsEDG8; Edg-8; S1P5; SPPR-1; SPPR-2
Alternate namessphingosine 1-phosphate receptor 5; S1P receptor 5; S1P receptor Edg-8; sphingosine 1-phosphate receptor EDG8; sphingosine 1-phosphate receptor Edg-8; endothelial differentiation G-protein-coupled receptor 8; endothelial differentiation, sphingolipid G-protein-coupled receptor, 8
Chromosome19
Map Location19p13.2
SummaryThe lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for S1PR5

Proteins

sphingosine 1-phosphate receptor 5
Refseq ID:NP_110387
Protein GI:13540517
UniProt ID:Q9H228
mRNA ID:NM_030760
Length:398
RefSeq Status:VALIDATED
MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLT
LKLSPALWFAREGGVFVALTASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDACSTVLPLYAKAYVLFCVLA
FVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSFSGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD
 
sphingosine 1-phosphate receptor 5
Refseq ID:NP_001159687
Protein GI:261278306
UniProt ID:Q9H228
mRNA ID:NM_001166215
Length:398
RefSeq Status:VALIDATED
Protein sequence is identical to GI:13540517 (mRNA isoform)