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LMP002490

Record overview

LMPD IDLMP002490
Gene ID14344
SpeciesMus musculus(Mouse)
Gene Namefucosyltransferase 2
Gene SymbolFut2
Synonyms-
Chromosome7
Map Location7 B4|7 29.41 cM
SummaryThis gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
OrthologsView orthologs and multiple alignments for Fut2

Proteins

galactoside 2-alpha-L-fucosyltransferase 2
Refseq ID:NP_061364
Protein GI:31542827
UniProt ID:Q9JL27
mRNA ID:NM_018876
Length:347
RefSeq Status:REVIEWED
MASAQVPFSFPLAHFLIFVFVTSTIIHLQQRIVKLQTLSEKELQAVQMSSPNAARTDMQQSAKLQGIFTINSIGRLGNQMGEYATLFALARMNGRLAFIP
ESMHNALAPIFRISLPVLHSDTARRIPWQNYHLNDWMEERYRHIPGQYVRFTGYPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLRVNGSQPSTFV
GVHVRRGDYVHVMPKVWKGVVADRGYLEKALDRFRARYSSPVFVVTSNGMAWCRENINTSLGDVVFAGNGIEGSPAKDFALLTQCNHTIMTIGTFGIWAA
YLAGGDTIYLANYTLPDSPFLKIFKPAAAFLPEWMGIPADLSPLLKH
 
galactoside 2-alpha-L-fucosyltransferase 2
Refseq ID:NP_001258922
Protein GI:431822426
UniProt ID:Q9JL27
mRNA ID:NM_001271993
Length:347
RefSeq Status:REVIEWED
Protein sequence is identical to GI:31542827 (mRNA isoform)