LMPD Database

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LMP002426

Record overview

LMPD IDLMP002426
Gene ID6439
SpeciesHomo sapiens (Human)
Gene Namesurfactant protein B
Gene SymbolSFTPB
SynonymsPSP-B; SFTB3; SFTP3; SMDP1; SP-B
Chromosome2
Map Location2p12-p11.2
SummaryThis gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, Feb 2010]
OrthologsView orthologs and multiple alignments for SFTPB

Proteins

pulmonary surfactant-associated protein B precursor
Refseq ID:NP_942140
Protein GI:288856297
UniProt ID:P07988
mRNA ID:NM_198843
Length:393
RefSeq Status:REVIEWED
MHQAGYPGCRGAMAESHLLQWLLLLLPTLCGPGTAAWTTSSLACAQGPEFWCQSLEQALQCRALGHCLQEVWGHVGADDLCQECEDIVHILNKMAKEAIF
QDTMRKFLEQECNVLPLKLLMPQCNQVLDDYFPLVIDYFQNQTDSNGICMHLGLCKSRQPEPEQEPGMSDPLPKPLRDPLPDPLLDKLVLPVLPGALQAR
PGPHTQDLSEQQFPIPLPYCWLCRALIKRIQAMIPKGALAVAVAQVCRVVPLVAGGICQCLAERYSVILLDTLLGRMLPQLVCRLVLRCSMDDSAGPRSP
TGEWLPRDSECHLCMSVTTQAGNSSEQAIPQAMLQACVGSWLDREKCKQFVEQHTPQLLTLVPRGWDAHTTCQALGVCGTMSSPLQCIHSPDL
 
sig_peptide: 1..36
calculated_mol_wt: 3779
peptide sequence: 
MHQAGYPGCRGAMAESHLLQWLLLLLPTLCGPGTAA

mat_peptide: 37..393
product: pulmonary surfactant-associated protein B
calculated_mol_wt: 39586
peptide sequence: 
WTTSSLACAQGPEFWCQSLEQALQCRALGHCLQEVWGHVGADDLCQECEDIVHILNKMAKEAIFQDTMRKFLEQECNVLPLKLLMPQCNQVLDDYFPLVI
DYFQNQTDSNGICMHLGLCKSRQPEPEQEPGMSDPLPKPLRDPLPDPLLDKLVLPVLPGALQARPGPHTQDLSEQQFPIPLPYCWLCRALIKRIQAMIPK
GALAVAVAQVCRVVPLVAGGICQCLAERYSVILLDTLLGRMLPQLVCRLVLRCSMDDSAGPRSPTGEWLPRDSECHLCMSVTTQAGNSSEQAIPQAMLQA
CVGSWLDREKCKQFVEQHTPQLLTLVPRGWDAHTTCQALGVCGTMSSPLQCIHSPDL

sig_peptide: 1..36
calculated_mol_wt: 3779
peptide sequence: 
MHQAGYPGCRGAMAESHLLQWLLLLLPTLCGPGTAA

mat_peptide: 37..393
product: pulmonary surfactant-associated protein B
calculated_mol_wt: 39586
peptide sequence: 
WTTSSLACAQGPEFWCQSLEQALQCRALGHCLQEVWGHVGADDLCQECEDIVHILNKMAKEAIFQDTMRKFLEQECNVLPLKLLMPQCNQVLDDYFPLVI
DYFQNQTDSNGICMHLGLCKSRQPEPEQEPGMSDPLPKPLRDPLPDPLLDKLVLPVLPGALQARPGPHTQDLSEQQFPIPLPYCWLCRALIKRIQAMIPK
GALAVAVAQVCRVVPLVAGGICQCLAERYSVILLDTLLGRMLPQLVCRLVLRCSMDDSAGPRSPTGEWLPRDSECHLCMSVTTQAGNSSEQAIPQAMLQA
CVGSWLDREKCKQFVEQHTPQLLTLVPRGWDAHTTCQALGVCGTMSSPLQCIHSPDL
 
pulmonary surfactant-associated protein B precursor
Refseq ID:NP_000533
Protein GI:288856299
UniProt ID:P07988
mRNA ID:NM_000542
Length:393
RefSeq Status:REVIEWED
Protein sequence is identical to GI:288856297 (mRNA isoform)