LMPD Database

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LMP002266

Record overview

LMPD IDLMP002266
Gene ID11019
SpeciesHomo sapiens (Human)
Gene Namelipoic acid synthetase
Gene SymbolLIAS
SynonymsLAS; LIP1; LS; PDHLD
Chromosome4
Map Location4p14
EC Number2.8.1.8
SummaryThe protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for LIAS

Proteins

lipoyl synthase, mitochondrial isoform 1 precursor
Refseq ID:NP_006850
Protein GI:37577166
UniProt ID:O43766
mRNA ID:NM_006859
Length:372
RefSeq Status:REVIEWED
MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNL
NLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHIAKTVSYL
KERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREAD
VDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKDL
 
lipoyl synthase, mitochondrial isoform 2 precursor
Refseq ID:NP_919433
Protein GI:37577164
UniProt ID:O43766
mRNA ID:NM_194451
Length:322
RefSeq Status:REVIEWED
MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNL
NLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHIAKTVSYL
KERNPKILVECLTPDFRGDLKAIEKVALSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREAD
VDCLTLGQYMQPTRRHLKVNFS
 
transit_peptide: 1..27
calculated_mol_wt: 3014
peptide sequence: 
MSLRCGDAARTLGPRVFGRYFCSPVRP

mat_peptide: 28..329
product: lipoyl synthase, mitochondrial isoform 3
calculated_mol_wt: 34141
peptide sequence: 
LSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATAT
ATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHIAKTVSYLKESKVRDPRANFDQSLRVLKHAKKVQP
DVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTK
DL

transit_peptide: 1..27
experiment: experimental evidence, no additional details recorded
note: Mitochondrion. {ECO:0000255|HAMAP-Rule:MF_03123}; propagated from UniProtKB/Swiss-Prot (O43766.3)
calculated_mol_wt: 3014
peptide sequence: 
MSLRCGDAARTLGPRVFGRYFCSPVRP

mat_peptide: 28..142
product: lipoyl synthase, mitochondrial isoform 4
calculated_mol_wt: 12806
peptide sequence: 
LSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATAT
ATIMVGPASTSMALV

transit_peptide: 1..27
calculated_mol_wt: 3014
peptide sequence: 
MSLRCGDAARTLGPRVFGRYFCSPVRP

mat_peptide: 28..100
product: lipoyl synthase, mitochondrial isoform 5
calculated_mol_wt: 8395
peptide sequence: 
LSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERYVRKLDVPILESVGEVENMPPPQPRSW

transit_peptide: 1..27
experiment: experimental evidence, no additional details recorded
note: Mitochondrion. {ECO:0000255|HAMAP-Rule:MF_03123}; propagated from UniProtKB/Swiss-Prot (O43766.3)
calculated_mol_wt: 3014
peptide sequence: 
MSLRCGDAARTLGPRVFGRYFCSPVRP

mat_peptide: 28..372
product: Lipoyl synthase, mitochondrial
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (O43766.3)
calculated_mol_wt: 38916
peptide sequence: 
LSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATAT
ATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVA
LSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEK
FKYWEKVGNELGFHYTASGPLVRSSYKAGEFFLKNLVAKRKTKDL

transit_peptide: 1..27
experiment: experimental evidence, no additional details recorded
note: Mitochondrion. {ECO:0000255|HAMAP-Rule:MF_03123}; propagated from UniProtKB/Swiss-Prot (O43766.3)
calculated_mol_wt: 3014
peptide sequence: 
MSLRCGDAARTLGPRVFGRYFCSPVRP

mat_peptide: 28..322
product: lipoyl synthase, mitochondrial isoform 2
calculated_mol_wt: 33067
peptide sequence: 
LSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNLNLHTVCEEARCPNIGECWGGGEYATAT
ATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHIAKTVSYLKERNPKILVECLTPDFRGDLKAIEKVA
LSGLDVYAHNVETVPELQSKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVNFS
 
lipoyl synthase, mitochondrial isoform 3 precursor
Refseq ID:NP_001265519
Protein GI:515869651
UniProt ID:O43766
mRNA ID:NM_001278590
Length:329
RefSeq Status:REVIEWED
MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNL
NLHTVCEEARCPNIGECWGGGEYATATATIMLMGDTCTRGCRFCSVKTARNPPPLDASEPYNTAKAIAEWGLDYVVLTSVDRDDMPDGGAEHIAKTVSYL
KESKVRDPRANFDQSLRVLKHAKKVQPDVISKTSIMLGLGENDEQVYATMKALREADVDCLTLGQYMQPTRRHLKVEEYITPEKFKYWEKVGNELGFHYT
ASGPLVRSSYKAGEFFLKNLVAKRKTKDL
 
lipoyl synthase, mitochondrial isoform 4 precursor
Refseq ID:NP_001265520
Protein GI:515869683
UniProt ID:Q6P5Q6
mRNA ID:NM_001278591
Length:142
RefSeq Status:REVIEWED
MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERLRLPPWLKTEIPMGKNYNKLKNTLRNL
NLHTVCEEARCPNIGECWGGGEYATATATIMVGPASTSMALV
 
lipoyl synthase, mitochondrial isoform 5 precursor
Refseq ID:NP_001265521
Protein GI:515869855
UniProt ID:O43766
mRNA ID:NM_001278592
Length:100
RefSeq Status:REVIEWED
MSLRCGDAARTLGPRVFGRYFCSPVRPLSSLPDKKKELLQNGPDLQDFVSGDLADRSTWDEYKGNLKRQKGERYVRKLDVPILESVGEVENMPPPQPRSW