LMPD Database

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LMP001992

Record overview

LMPD IDLMP001992
Gene ID9487
SpeciesHomo sapiens (Human)
Gene Namephosphatidylinositol glycan anchor biosynthesis, class L
Gene SymbolPIGL
SynonymsCHIME
Alternate namesN-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; PIG-L; phosphatidylinositol glycan, class L; N-acetylglucosaminylphosphatidylinositol deacetylase; phosphatidylinositol-glycan biosynthesis class L protein
Chromosome17
Map Location17p12-p11.2
EC Number3.5.1.89
SummaryThis gene encodes an enzyme that catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI). Study of a similar rat enzyme suggests that this protein localizes to the endoplasmic reticulum. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PIGL

Proteins

N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase precursor
Refseq ID:NP_004269
Protein GI:4758922
UniProt ID:Q9Y2B2
mRNA ID:NM_004278
Length:252
RefSeq Status:REVIEWED
MEAMWLLCVALAVLAWGFLWVWDSSERMKSREQGGRLGAESRTLLVIAHPDDEAMFFAPTVLGLARLRHWVYLLCFSAGNYYNQGETRKKELLQSCDVLG
IPLSSVMIIDNRDFPDDPGMQWDTEHVARVLLQHIEVNGINLVVTFDAGGVSGHSNHIALYAAVRALHSEGKLPKGCSVLTLQSVNVLRKYISLLDLPLS
LLHTQDVLFVLNSKEVAQAKKAMSCHRSQLLWFRRLYIIFSRYMRINSLSFL
 
sig_peptide: 1..17
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1877
peptide sequence: 
MEAMWLLCVALAVLAWG