LMPD Database

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LMP001960

Record overview

LMPD IDLMP001960
Gene ID7274
SpeciesHomo sapiens (Human)
Gene Nametocopherol (alpha) transfer protein
Gene SymbolTTPA
SynonymsATTP; AVED; TTP1; alphaTTP
Alternate namesalpha-tocopherol transfer protein; alpha-TTP; tocopherol (alpha) transfer protein (ataxia (Friedreich-like) with vitamin E deficiency)
Chromosome8
Map Location8q12.3
SummaryThis gene encodes a soluble protein that binds alpha-trocopherol, a form of vitamin E, with high selectivity and affinity. This protein plays an important role in regulating vitamin E levels in the body by transporting vitamin E between membrane vesicles and facilitating the secretion of vitamin E from hepatocytes to circulating lipoproteins. Mutations in this gene cause hereditary vitamin E deficiency (ataxia with vitamin E deficiency, AVED) and retinitis pigmentosa. [provided by RefSeq, Nov 2009]
OrthologsView orthologs and multiple alignments for TTPA

Proteins

alpha-tocopherol transfer protein
Refseq ID:NP_000361
Protein GI:4507723
UniProt ID:P49638
mRNA ID:NM_000370
Length:278
RefSeq Status:REVIEWED
MAEARSQPSAGPQLNALPDHSPLLQPGLAALRRRAREAGVPLAPLPLTDSFLLRFLRARDFDLDLAWRLLKNYYKWRAECPEISADLHPRSIIGLLKAGY
HGVLRSRDPTGSKVLIYRIAHWDPKVFTAYDVFRVSLITSELIVQEVETQRNGIKAIFDLEGWQFSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINEP
VIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHFPDILPLEYGGEEFSMEDICQEWTNFIMKSEDYLSSISESIQ