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LMP001702

Record overview

LMPD IDLMP001702
Gene ID6554
SpeciesHomo sapiens (Human)
Gene Namesolute carrier family 10 (sodium/bile acid cotransporter), member 1
Gene SymbolSLC10A1
SynonymsNTCP
Chromosome14
Map Location14q24.1
SummaryThe protein encoded by this gene belongs to the sodium/bile acid cotransporter family, which are integral membrane glycoproteins that participate in the enterohepatic circulation of bile acids. Two homologous transporters are involved in the reabsorption of bile acids; the ileal sodium/bile acid cotransporter with an apical cell localization that absorbs bile acids from the intestinal lumen, bile duct and kidney, and the liver-specific sodium/bile acid cotransporter, represented by this protein, that is found in the basolateral membranes of hepatocytes. Bile acids are the catabolic product of cholesterol metabolism, hence this protein is important for cholesterol homeostasis. [provided by RefSeq, Oct 2011]
OrthologsView orthologs and multiple alignments for SLC10A1

Proteins

sodium/bile acid cotransporter
Refseq ID:NP_003040
Protein GI:4506971
UniProt ID:Q14973
mRNA ID:NM_003049
Length:349
RefSeq Status:REVIEWED
MEAHNASAPFNFTLPPNFGKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKGLAIALVAQYGIMPLTAFVLGKVFRLKNIEALAILVCGCSP
GGNLSNVFSLAMKGDMNLSIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLIPCTIGIVLKSKRPQYMRYVIKGGMIIILLCSV
AVTVLSAINVGKSIMFAMTPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCSTILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLL
IAIFWCYEKFKTPKDKTKMIYTAATTEETIPGALGNGTYKGEDCSPCTA