LMPD Database

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LMP001572

Record overview

LMPD IDLMP001572
Gene ID3612
SpeciesHomo sapiens (Human)
Gene Nameinositol(myo)-1(or 4)-monophosphatase 1
Gene SymbolIMPA1
SynonymsIMP; IMPA
Alternate namesinositol monophosphatase 1; IMP 1; IMPase 1; inositol-1(or 4)-monophosphatase 1; D-galactose 1-phosphate phosphatase; lithium-sensitive myo-inositol monophosphatase A1
Chromosome8
Map Location8q21.13-q21.3
EC Number3.1.3.25
SummaryThis gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009]
OrthologsView orthologs and multiple alignments for IMPA1

Proteins

inositol monophosphatase 1 isoform 1
Refseq ID:NP_005527
Protein GI:5031789
UniProt ID:P29218
mRNA ID:NM_005536
Length:277
RefSeq Status:REVIEWED
MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVH
RFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNM
CLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGGPFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED
 
inositol monophosphatase 1 isoform 2
Refseq ID:NP_001138350
Protein GI:221625487
UniProt ID:P29218
mRNA ID:NM_001144878
Length:336
RefSeq Status:REVIEWED
MGQRPGPVLPAVAVLGQVAKRKVAWLLRWKAVTRTETAGNSSGVYGFGKMKIFVKYFQKMADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVD
LVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVHRFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFC
NGQKLQVSQQEDITKSLLVTELGSSRTPETVRMVLSNMEKLFCIPVHGIRSVGTAAVNMCLVATGGADAYYEMGIHCWDVAGAGIIVTEAGGVLMDVTGG
PFDLMSRRVIAANNRILAERIAKEIQVIPLQRDDED
 
inositol monophosphatase 1 isoform 3
Refseq ID:NP_001138351
Protein GI:221625507
UniProt ID:P29218
mRNA ID:NM_001144879
Length:198
RefSeq Status:REVIEWED
MADPWQECMDYAVTLARQAGEVVCEAIKNEMNVMLKSSPVDLVTATDQKVEKMLISSIKEKYPSHSFIGEESVAAGEKSILTDNPTWIIDPIDGTTNFVH
RFPFVAVSIGFAVNKKIEFGVVYSCVEGKMYTARKGKGAFCNGQKLQVSQQEGSGVLEQQLLICALWQLAEQMHIMKWEFTAGMLQELALLLLKLVAC