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LMP001444

Record overview

LMPD IDLMP001444
Gene ID11814
SpeciesMus musculus(Mouse)
Gene Nameapolipoprotein C-III
Gene SymbolApoc3
Synonymsapo-CIII; apoC-III
Chromosome9
Map Location9 A5.2|9 25.36 cM
SummaryThis gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
OrthologsView orthologs and multiple alignments for Apoc3

Proteins

apolipoprotein C-III isoform a
Refseq ID:NP_001276684
Protein GI:577019552
UniProt ID:E9QP56
mRNA ID:NM_001289755
Length:137
RefSeq Status:REVIEWED
MPLGRRGRKGRNKELEGEALTTQPSSPQKAWDSWYVGAMQPRTLLTVALLALLASARAEEVEGSLLLGSVQGYMEQASKTVQDALSSVQESDIAVVARGW
MDNHFRSLKGYWSKFTDKFTGFWDSNPEDQPTPAIES
 
apolipoprotein C-III isoform b precursor
Refseq ID:NP_075603
Protein GI:15421856
UniProt ID:P33622
mRNA ID:NM_023114
Length:99
RefSeq Status:REVIEWED
MQPRTLLTVALLALLASARAEEVEGSLLLGSVQGYMEQASKTVQDALSSVQESDIAVVARGWMDNHFRSLKGYWSKFTDKFTGFWDSNPEDQPTPAIES
 
sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2110
peptide sequence: 
MQPRTLLTVALLALLASARA

mat_peptide: 21..99
product: Apolipoprotein C-III
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P33622.2)
calculated_mol_wt: 8831
peptide sequence: 
EEVEGSLLLGSVQGYMEQASKTVQDALSSVQESDIAVVARGWMDNHFRSLKGYWSKFTDKFTGFWDSNPEDQPTPAIES

sig_peptide: 1..20
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2110
peptide sequence: 
MQPRTLLTVALLALLASARA

mat_peptide: 21..99
product: Apolipoprotein C-III
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P33622.2)
calculated_mol_wt: 8831
peptide sequence: 
EEVEGSLLLGSVQGYMEQASKTVQDALSSVQESDIAVVARGWMDNHFRSLKGYWSKFTDKFTGFWDSNPEDQPTPAIES
 
apolipoprotein C-III isoform b precursor
Refseq ID:NP_001276685
Protein GI:577019554
UniProt ID:P33622
mRNA ID:NM_001289756
Length:99
RefSeq Status:REVIEWED
Protein sequence is identical to GI:15421856 (mRNA isoform)