LMPD Database

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LMP001404

Record overview

LMPD IDLMP001404
Gene ID27349
SpeciesHomo sapiens (Human)
Gene Namemalonyl CoA:ACP acyltransferase (mitochondrial)
Gene SymbolMCAT
SynonymsFASN2C; MCT; MT; NET62; fabD
Alternate namesmalonyl-CoA-acyl carrier protein transacylase, mitochondrial; mitochondrial malonyltransferase; [Acyl-carrier-protein] malonyltransferase; mitochondrial malonyl CoA:ACP acyltransferase; malonyl-CoA:acyl carrier protein transacylase, mitochondrial
Chromosome22
Map Location22q13.31
EC Number2.3.1.39
SummaryThe protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]
OrthologsView orthologs and multiple alignments for MCAT

Proteins

malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform a precursor
Refseq ID:NP_775738
Protein GI:51243059
UniProt ID:Q8IVS2
mRNA ID:NM_173467
Length:390
RefSeq Status:REVIEWED
MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGY
DLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGLYAVKIRAEAMQEASEAVPSGMLSVLGQP
QSKFNFACLEAREHCKSLGIENPVCEVSNYLFPDCRVISGHQEALRFLQKNSSKFHFRRTRMLPVSGAFHTRLMEPAVEPLTQALKAVDIKKPLVSVYSN
VHAHRYRHPGHIHKLLAQQLVSPVKWEQTMHAIYERKKGRGFPQTFEVGPGRQLGAILKSCNMQAWKSYSAVDVLQTLEHVDLDPQEPPR
 
transit_peptide: 1..21
calculated_mol_wt: 2348
peptide sequence: 
MSVRVARVAWVRGLGASYRRG

mat_peptide: 22..180
product: malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform b
calculated_mol_wt: 16846
peptide sequence: 
ASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGYDLLELSLHGPQETLDRTVHCQ
PAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGSTVSPEEFL

transit_peptide: 1..21
calculated_mol_wt: 2348
peptide sequence: 
MSVRVARVAWVRGLGASYRRG

mat_peptide: 22..390
product: malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform a
calculated_mol_wt: 40632
peptide sequence: 
ASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGYDLLELSLHGPQETLDRTVHCQ
PAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGLYAVKIRAEAMQEASEAVPSGMLSVLGQPQSKFNFACLEAREHCKSLGIE
NPVCEVSNYLFPDCRVISGHQEALRFLQKNSSKFHFRRTRMLPVSGAFHTRLMEPAVEPLTQALKAVDIKKPLVSVYSNVHAHRYRHPGHIHKLLAQQLV
SPVKWEQTMHAIYERKKGRGFPQTFEVGPGRQLGAILKSCNMQAWKSYSAVDVLQTLEHVDLDPQEPPR
 
malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform b precursor
Refseq ID:NP_055322
Protein GI:27477045
UniProt ID:Q8IVS2
mRNA ID:NM_014507
Length:180
RefSeq Status:REVIEWED
MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATGAEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGY
DLLELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAALVFAGAMEFAEGSTVSPEEFL