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LMP001364

Record overview

LMPD IDLMP001364
Gene ID2819
SpeciesHomo sapiens (Human)
Gene Nameglycerol-3-phosphate dehydrogenase 1 (soluble)
Gene SymbolGPD1
SynonymsGPD-C; GPDH-C; HTGTI
Alternate namesglycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic; glycerophosphate dehydrogenase; glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic
Chromosome12
Map Location12q13.12
EC Number1.1.1.8
SummaryThis gene encodes a member of the NAD-dependent glycerol-3-phosphate dehydrogenase family. The encoded protein plays a critical role in carbohydrate and lipid metabolism by catalyzing the reversible conversion of dihydroxyacetone phosphate (DHAP) and reduced nicotine adenine dinucleotide (NADH) to glycerol-3-phosphate (G3P) and NAD+. The encoded cytosolic protein and mitochondrial glycerol-3-phosphate dehydrogenase also form a glycerol phosphate shuttle that facilitates the transfer of reducing equivalents from the cytosol to mitochondria. Mutations in this gene are a cause of transient infantile hypertriglyceridemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
OrthologsView orthologs and multiple alignments for GPD1

Proteins

glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 1
Refseq ID:NP_005267
Protein GI:33695088
UniProt ID:P21695
mRNA ID:NM_005276
Length:349
RefSeq Status:REVIEWED
MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVVAVPDVVQAAEDADILIFVVPHQFIGK
ICDQLKGHLKANATGISLIKGVDEGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEIC
GALKNVVAVGAGFCDGLGFGDNTKAAVIRLGLMEMIAFAKLFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGP
ETARELYSILQHKGLVDKFPLFMAVYKVCYEGQPVGEFIHCLQNHPEHM
 
glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic isoform 2
Refseq ID:NP_001244128
Protein GI:380714668
UniProt ID:P21695
mRNA ID:NM_001257199
Length:326
RefSeq Status:REVIEWED
MASKKVCIVGSGNWGSAIAKIVGGNAAQLAQFDPRVTMWVFEEDIGGKKLTEIINTQHENVKYLPGHKLPPNVFIGKICDQLKGHLKANATGISLIKGVD
EGPNGLKLISEVIGERLGIPMSVLMGANIASEVADEKFCETTIGCKDPAQGQLLKELMQTPNFRITVVQEVDTVEICGALKNVVAVGAGFCDGLGFGDNT
KAAVIRLGLMEMIAFAKLFCSGPVSSATFLESCGVADLITTCYGGRNRKVAEAFARTGKSIEQLEKELLNGQKLQGPETARELYSILQHKGLVDKFPLFM
AVYKVCYEGQPVGEFIHCLQNHPEHM