LMPD Database

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LMP001191

Record overview

LMPD IDLMP001191
Gene ID2878
SpeciesHomo sapiens (Human)
Gene Nameglutathione peroxidase 3 (plasma)
Gene SymbolGPX3
SynonymsGPx-P; GSHPx-3; GSHPx-P
Alternate namesglutathione peroxidase 3; GPx-3; plasma glutathione peroxidase; extracellular glutathione peroxidase
Chromosome5
Map Location5q23
EC Number1.11.1.9
SummaryThis gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for GPX3

Proteins

glutathione peroxidase 3 precursor
Refseq ID:NP_002075
Protein GI:6006001
UniProt ID:P22352
mRNA ID:NM_002084
Length:226
RefSeq Status:REVIEWED
MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFP
CNQFGKQEPGENSEILPTLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHH
RTTVSNVKMDILSYMRRQAALGVKRK
 
sig_peptide: 1..20
calculated_mol_wt: 2107
peptide sequence: 
MARLLQASCLLSLLLAGFVS

mat_peptide: 21..226
product: glutathione peroxidase 3
calculated_mol_wt: 23464
peptide sequence: 
QSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLK
YVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAA
LGVKRK