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LMP001132

Record overview

LMPD IDLMP001132
Gene ID36
SpeciesHomo sapiens (Human)
Gene Nameacyl-CoA dehydrogenase, short/branched chain
Gene SymbolACADSB
Synonyms2-MEBCAD; ACAD7; SBCAD
Alternate namesshort/branched chain specific acyl-CoA dehydrogenase, mitochondrial; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methyl branched chain acyl-CoA dehydrogenase; acyl-Coenzyme A dehydrogenase, short/branched chain
Chromosome10
Map Location10q26.13
EC Number1.3.8.5
SummaryShort/branched chain acyl-CoA dehydrogenase(ACADSB) is a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Substrate specificity is the primary characteristic used to define members of this gene family. The ACADSB gene product has the greatest activity towards the short branched chain acyl-CoA derivative, (S)-2-methylbutyryl-CoA, but also reacts significantly with other 2-methyl branched chain substrates and with short straight chain acyl-CoAs. The cDNA encodes for a mitochondrial precursor protein which is cleaved upon mitochondrial import and predicted to yield a mature peptide of approximately 43.7-KDa. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ACADSB

Proteins

short/branched chain specific acyl-CoA dehydrogenase, mitochondrial precursor
Refseq ID:NP_001600
Protein GI:4501859
UniProt ID:P45954
mRNA ID:NM_001609
Length:432
RefSeq Status:REVIEWED
MEGLAVRLLRGSRLLRRNFLTCLSSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQ
GLMGIEVDPEYGGTGASFLSTVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVGSFCLSEAGAGSDSFALKTRADKEGDYYV
LNGSKMWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQ
MLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPV
EKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY
 
transit_peptide: 1..33
calculated_mol_wt: 3808
peptide sequence: 
MEGLAVRLLRGSRLLRRNFLTCLSSWKIPPHVS

mat_peptide: 34..432
product: short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
calculated_mol_wt: 43696
peptide sequence: 
KSSQSEALLNITNNGIHFAPLQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAKVDA
SVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVGSFCLSEAGAGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDPTIGYKGIT
SFLVDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQ
HQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY