LMPD Database

LMP001046

Record overview

LMPD IDLMP001046
Gene ID1891
SpeciesHomo sapiens (Human)
Gene Nameenoyl CoA hydratase 1, peroxisomal
Gene SymbolECH1
SynonymsHPXEL
Alternate namesdelta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial; dienoyl-CoA isomerase; peroxisomal enoyl-CoA hydratase 1; delta3,5-delta2,4-dienoyl-CoA isomerase; enoyl Coenzyme A hydratase 1, peroxisomal
Chromosome19
Map Location19q13.1
EC Number5.3.3.-
SummaryThis gene encodes a member of the hydratase/isomerase superfamily. The gene product shows high sequence similarity to enoyl-coenzyme A (CoA) hydratases of several species, particularly within a conserved domain characteristic of these proteins. The encoded protein, which contains a C-terminal peroxisomal targeting sequence, localizes to the peroxisome. The rat ortholog, which localizes to the matrix of both the peroxisome and mitochondria, can isomerize 3-trans,5-cis-dienoyl-CoA to 2-trans,4-trans-dienoyl-CoA, indicating that it is a delta3,5-delta2,4-dienoyl-CoA isomerase. This enzyme functions in the auxiliary step of the fatty acid beta-oxidation pathway. Expression of the rat gene is induced by peroxisome proliferators. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ECH1

Proteins

delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor
Refseq ID:NP_001389
Protein GI:70995211
UniProt ID:Q13011
mRNA ID:NM_001398
Length:328
RefSeq Status:REVIEWED
MAAGIVASRRLRDLLTRRLTGSNYPGLSISLRLTGSSAQEEASGVALGEAPDHSYESLRVTSAQKHVLHVQLNRPNKRNAMNKVFWREMVECFNKISRDA
DCRAVVISGAGKMFTAGIDLMDMASDILQPKGDDVARISWYLRDIITRYQETFNVIERCPKPVIAAVHGGCIGGGVDLVTACDIRYCAQDAFFQVKEVDV
GLAADVGTLQRLPKVIGNQSLVNELAFTARKMMADEALGSGLVSRVFPDKEVMLDAALALAAEISSKSPVAVQSTKVNLLYSRDHSVAESLNYVASWNMS
MLQTQDLVKSVQATTENKELKTVTFSKL