LMPD Database

LMP001000

UniProt Annotations

Entry Information
Gene NameST3 beta-galactoside alpha-2,3-sialyltransferase 4
Protein EntrySIA4C_HUMAN
UniProt IDQ11206
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=7; Name=1; Synonyms=B1; IsoId=Q11206-1; Sequence=Displayed; Name=2; Synonyms=A1; IsoId=Q11206-2; Sequence=VSP_001784; Name=3; Synonyms=A2; IsoId=Q11206-3; Sequence=VSP_001785; Name=4; Synonyms=C; IsoId=Q11206-4; Sequence=VSP_001786; Name=5; IsoId=Q11206-5; Sequence=VSP_021104; Name=6; IsoId=Q11206-6; Sequence=VSP_001784, VSP_021104; Name=7; IsoId=Q11206-7; Sequence=VSP_001785, VSP_021104;
Catalytic ActivityCMP-N-acetylneuraminate + beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D- glucosaminyl-glycoprotein.
FunctionIt may catalyze the formation of the NeuAc-alpha-2,3- Gal-beta-1,3-GalNAc- or NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. It may be involved in the biosynthesis of the sialyl Lewis X determinant. Also acts on the corresponding 1,3- galactosyl derivative.
PathwayProtein modification; protein glycosylation.
PtmThe soluble form derives from the membrane form by proteolytic processing.
SimilarityBelongs to the glycosyltransferase 29 family.
Subcellular LocationGolgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.
Tissue SpecificityHighly expressed in adult placenta, ovary and testes.
Web ResourceName=Functional Glycomics Gateway - GTase; Note=ST3Gal IV; URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_625";
Web ResourceName=GGDB; Note=GlycoGene database; URL="http://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ST3GAL4";