LMPD Database

LMP000658

Record overview

LMPD IDLMP000658
Gene ID53632
SpeciesHomo sapiens (Human)
Gene Nameprotein kinase, AMP-activated, gamma 3 non-catalytic subunit
Gene SymbolPRKAG3
SynonymsAMPKG3
Alternate names5'-AMP-activated protein kinase subunit gamma-3;,AMPK gamma3; AMPK gamma-3 chain; AMPK subunit gamma-3', "5'-AMP-activated protein kinase, gamma-3 subunit
Chromosome2
Map Location2q35
SummaryThe protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PRKAG3

Proteins

5'-AMP-activated protein kinase subunit gamma-3
Refseq ID:NP_059127
Protein GI:47132577
UniProt ID:Q9UGI9
mRNA ID:NM_017431
Length:489
RefSeq Status:REVIEWED
MEPGLEHALRRTPSWSSLGGSEHQEMSFLEQENSSSWPSPAVTSSSERIRGKRRAKALRWTRQKSVEEGEPPGQGEGPRSRPAAESTGLEATFPKTTPLA
QADPAGVGTPPTGWDCLPSDCTASAAGSSTDDVELATEFPATEAWECELEGLLEERPALCLSPQAPFPKLGWDDELRKPGAQIYMRFMQEHTCYDAMATS
SKLVIFDTMLEIKKAFFALVANGVRAAPLWDSKKQSFVGMLTITDFILVLHRYYRSPLVQIYEIEQHKIETWREIYLQGCFKPLVSISPNDSLFEAVYTL
IKNRIHRLPVLDPVSGNVLHILTHKRLLKFLHIFGSLLPRPSFLYRTIQDLGIGTFRDLAVVLETAPILTALDIFVDRRVSALPVVNECGQVVGLYSRFD
VIHLAAQQTYNHLDMSVGEALRQRTLCLEGVLSCQPHESLGEVIDRIAREQVHRLVLVDETQHLLGVVSLSDILQALVLSPAGIDALGA