LMPD Database

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LMP000630

Record overview

LMPD IDLMP000630
Gene ID23417
SpeciesHomo sapiens (Human)
Gene Namemalonyl-CoA decarboxylase
Gene SymbolMLYCD
SynonymsMCD
Alternate namesmalonyl-CoA decarboxylase, mitochondrial; malonyl coenzyme A decarboxylase
Chromosome16
Map Location16q24
EC Number4.1.1.9
SummaryThe product of this gene catalyzes the breakdown of malonyl-CoA to acetyl-CoA and carbon dioxide. Malonyl-CoA is an intermediate in fatty acid biosynthesis, and also inhibits the transport of fatty acyl CoAs into mitochondria. Consequently, the encoded protein acts to increase the rate of fatty acid oxidation. It is found in mitochondria, peroxisomes, and the cytoplasm. Mutations in this gene result in malonyl-CoA decarboyxlase deficiency. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for MLYCD

Proteins

malonyl-CoA decarboxylase, mitochondrial
Refseq ID:NP_036345
Protein GI:110349750
UniProt ID:O95822
mRNA ID:NM_012213
Length:493
RefSeq Status:REVIEWED
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHG
QVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERV
TWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQG
VELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMR
LCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL