LMPD Database

LMP000538

Record overview

LMPD IDLMP000538
Gene ID56632
SpeciesMus musculus(Mouse)
Gene Namesphingosine kinase 2
Gene SymbolSphk2
SynonymsC76851
Chromosome7
Map Location7 B4|7
SummaryThis gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. The gene product also enhances apoptosis in different cell types and suppresses cellular proliferation. In mast cells, the encoded protein is necessary for influx of calcium, protein kinase C activation, and cytokine production and degranulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
OrthologsView orthologs and multiple alignments for Sphk2

Proteins

sphingosine kinase 2
Refseq ID:NP_001166032
Protein GI:289191399
UniProt ID:Q58E38
mRNA ID:NM_001172561
Length:617
RefSeq Status:REVIEWED
MAPPPLLPVAASTPILHGEFGSYPANGPRFALTLTTQALHIQRLRPKPEARPRDGLVSLDEVSGCGTLQSRSPEDTAAYFCIYTYPRGRRGGRRRATRTF
RADGATTYEENRAEAQRWATALTCLLRGVPLSGDQEITPELLPRKPRLLILVNPFGGRGLAWQRCMDHVVPMISEAGLSFNLIQTERQNHARELVQGLSL
SEWEGIVTVSGDGLLYEVLNGLLDRPDWEDAVRMPIGVLPCGSGNALAGAVNHHGGFEQVVGVDLLLNCSLLLCRGGSHPLDLLSVTLASGSRCFSFLSV
AWGFLSDVDIHSERFRALGSARFTLGAVLGLASLHTYRGRLSYLPATTEPALPIPGHSLPRAKSELVLAPAPAPAATHSPLHRSVSDLPLPLPQPALVSP
GSPEPLPDLSLNGGGPELTGDWGGAGDAPLSPDPLLPSSPNALKTAQLSPIAEGPPEMPASSGFLPPTHSAPEASTWGPVDHLLPPLGSPLPQDWVTIEG
EFVLMLGILPSHLCADLMAAPHARFDDGVVHLCWVRSGISRAALLRILLAMEHGNHFSLGCPHLGYAAARAFRLEPLTPRGLLTVDGELVEYGPIQAQVH
PGLATLLTGPAGQKPQA
 
sphingosine kinase 2
Refseq ID:NP_975009
Protein GI:42544000
UniProt ID:Q3U912
mRNA ID:NM_203280
Length:617
RefSeq Status:REVIEWED
Protein sequence is identical to GI:289191399 (mRNA isoform)
 
sphingosine kinase 2
Refseq ID:NP_064395
Protein GI:31981070
UniProt ID:Q58E38
mRNA ID:NM_020011
Length:617
RefSeq Status:REVIEWED
Protein sequence is identical to GI:289191399 (mRNA isoform)