LMPD Database

LMP000300

Record overview

LMPD IDLMP000300
Gene ID11806
SpeciesMus musculus(Mouse)
Gene Nameapolipoprotein A-I
Gene SymbolApoa1
SynonymsAlp-1; Apoa-1; Brp-14; Ltw-1; Lvtw-1; Sep-1; Sep-2; Sep2; apo-AI; apoA-I
Alternate namesapolipoprotein A-I; apolipoprotein A1
Chromosome9
Map Location9 A2-A4|9 25.36 cM
SummaryThis gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is the major protein component of plasma high density lipoprotein (HDL). This protein facilitates the removal of cholesterol and other fats from tissues by transporting them to the liver for excretion. This protein is a cofactor for lecithin cholesterolacyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. Mutations in this gene in humans causes familial HDL deficiency, Tangier disease and familial visceral amyloidosis. Similar clinical features are exhibited by mice with mutations in this gene. This gene is clustered with three other apolipoprotein genes on chromosome 9. [provided by RefSeq, Dec 2013]
OrthologsView orthologs and multiple alignments for Apoa1

Proteins

apolipoprotein A-I preproprotein
Refseq ID:NP_033822
Protein GI:160333304
UniProt ID:Q00623
mRNA ID:NM_009692
Length:264
RefSeq Status:REVIEWED
MKAVVLAVALVFLTGSQAWHVWQQDEPQSQWDKVKDFANVYVDAVKDSGRDYVSQFESSSLGQQLNLNLLENWDTLGSTVSQLQERLGPLTRDFWDNLEK
ETDWVRQEMNKDLEEVKQKVQPYLDEFQKKWKEDVELYRQKVAPLGAELQESARQKLQELQGRLSPVAEEFRDRMRTHVDSLRTQLAPHSEQMRESLAQR
LAELKSNPTLNEYHTRAKTHLKTLGEKARPALEDLRHSLMPMLETLKTQVQSVIDKASETLTAQ
 
sig_peptide: 1..18
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 1818
peptide sequence: 
MKAVVLAVALVFLTGSQA

mat_peptide: 19..264
product: Proapolipoprotein A-I
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q00623.2)
calculated_mol_wt: 28815
peptide sequence: 
WHVWQQDEPQSQWDKVKDFANVYVDAVKDSGRDYVSQFESSSLGQQLNLNLLENWDTLGSTVSQLQERLGPLTRDFWDNLEKETDWVRQEMNKDLEEVKQ
KVQPYLDEFQKKWKEDVELYRQKVAPLGAELQESARQKLQELQGRLSPVAEEFRDRMRTHVDSLRTQLAPHSEQMRESLAQRLAELKSNPTLNEYHTRAK
THLKTLGEKARPALEDLRHSLMPMLETLKTQVQSVIDKASETLTAQ mat_peptide: 25..264 product: Apolipoprotein A-I experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q00623.2) calculated_mol_wt: 27950 peptide sequence: DEPQSQWDKVKDFANVYVDAVKDSGRDYVSQFESSSLGQQLNLNLLENWDTLGSTVSQLQERLGPLTRDFWDNLEKETDWVRQEMNKDLEEVKQKVQPYL
DEFQKKWKEDVELYRQKVAPLGAELQESARQKLQELQGRLSPVAEEFRDRMRTHVDSLRTQLAPHSEQMRESLAQRLAELKSNPTLNEYHTRAKTHLKTL
GEKARPALEDLRHSLMPMLETLKTQVQSVIDKASETLTAQ mat_peptide: 25..263 product: Truncated apolipoprotein A-I (By similarity) inference: non-experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q00623.2) calculated_mol_wt: 27822 peptide sequence: DEPQSQWDKVKDFANVYVDAVKDSGRDYVSQFESSSLGQQLNLNLLENWDTLGSTVSQLQERLGPLTRDFWDNLEKETDWVRQEMNKDLEEVKQKVQPYL
DEFQKKWKEDVELYRQKVAPLGAELQESARQKLQELQGRLSPVAEEFRDRMRTHVDSLRTQLAPHSEQMRESLAQRLAELKSNPTLNEYHTRAKTHLKTL
GEKARPALEDLRHSLMPMLETLKTQVQSVIDKASETLTA