LMPD Database

LMP000280

UniProt Annotations

Entry Information
Gene Namedelta(4)-desaturase, sphingolipid 1
Protein EntryDEGS1_HUMAN
UniProt IDO15121
SpeciesHuman
Comments
Comment typeDescription
FunctionHas sphingolipid-delta-4-desaturase activity. Converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine).
InteractionP11217:PYGM; NbExp=1; IntAct=EBI-1052713, EBI-357469; P53985:SLC16A1; NbExp=1; IntAct=EBI-1052713, EBI-1054708; O15260:SURF4; NbExp=1; IntAct=EBI-1052713, EBI-1044848; Q53HC9:TSSC1; NbExp=1; IntAct=EBI-1052713, EBI-1055422;
PtmMyristoylation can target the enzyme to the mitochondria leading to an increase in ceramide levels.
SimilarityBelongs to the fatty acid desaturase family. DEGS subfamily.
Subcellular LocationMitochondrion. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue SpecificityUbiquitous.