LMPD Database

LMP000247

Record overview

LMPD IDLMP000247
Gene ID5465
SpeciesHomo sapiens (Human)
Gene Nameperoxisome proliferator-activated receptor alpha
Gene SymbolPPARA
SynonymsNR1C1; PPAR; PPARalpha; hPPAR
Chromosome22
Map Location22q13.31
SummaryPeroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for PPARA

Proteins

peroxisome proliferator-activated receptor alpha
Refseq ID:NP_001001928
Protein GI:50348666
UniProt ID:Q07869
mRNA ID:NM_001001928
Length:468
RefSeq Status:REVIEWED
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNI
ECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSET
ADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANL
DLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKM
QEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
 
peroxisome proliferator-activated receptor alpha
Refseq ID:NP_005027
Protein GI:7549811
UniProt ID:Q07869
mRNA ID:NM_005036
Length:468
RefSeq Status:REVIEWED
Protein sequence is identical to GI:50348666 (mRNA isoform)