LMPD Database

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LMP000078

UniProt Annotations

Entry Information
Gene Namephospholipase C, eta 2
Protein EntryPLCH2_HUMAN
UniProt IDO75038
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=5; Name=1; IsoId=O75038-1; Sequence=Displayed; Name=2; IsoId=O75038-2; Sequence=VSP_029068, VSP_029072, VSP_029073; Name=3; IsoId=O75038-3; Sequence=VSP_029070; Note=No experimental confirmation available.; Name=4; IsoId=O75038-4; Sequence=VSP_029071, VSP_029074; Note=No experimental confirmation available. Ref.2 (BAB84975) sequence is in conflict in position: 1004:P->L. ; Name=5; IsoId=O75038-5; Sequence=VSP_029067, VSP_029069, VSP_029071, VSP_029074; Note=No experimental confirmation available. Ref.2 (BAC56932) sequence is in conflict in position: 209:Q->L. ;
Catalytic Activity1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
CofactorName=Ca(2+); Xref=ChEBI
FunctionThe production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity).
Sequence CautionSequence=AAH43358.1; Type=Frameshift; Positions=172; Evidence= ; Sequence=BAA32295.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ; Sequence=BAC56932.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
SimilarityContains 1 C2 domain. {ECO
SimilarityContains 1 PH domain. {ECO
SimilarityContains 1 PI-PLC X-box domain. {ECO
SimilarityContains 1 PI-PLC Y-box domain. {ECO
SimilarityContains 2 EF-hand domains. {ECO
Subcellular LocationCytoplasm. Cell membrane. Note=Localized predominantly at the plasma membrane.
Tissue SpecificityExpressed in retina and kidney.