LMPD Database

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LMP000072

UniProt Annotations

Entry Information
Gene Nameacyl-CoA dehydrogenase, long chain
Protein EntryACADL_HUMAN
UniProt IDP28330
SpeciesHuman
Comments
Comment typeDescription
Catalytic ActivityLong-chain-acyl-CoA + electron-transfer flavoprotein = long-chain-2,3-dehydroacyl-CoA + reduced electron- transfer flavoprotein.
CofactorName=FAD; Xref=ChEBI
DiseaseAcyl-CoA dehydrogenase very long-chain deficiency (ACADVLD) [MIM
MiscellaneousA number of straight-chain acyl-CoA dehydrogenases of different substrate specificities are present in mammalian tissues.
PathwayLipid metabolism; mitochondrial fatty acid beta- oxidation.
PtmAcetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3 (By similarity).
SimilarityBelongs to the acyl-CoA dehydrogenase family.
Subcellular LocationMitochondrion matrix.
SubunitHomotetramer.