LMPD Database

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LMP000072

Record overview

LMPD IDLMP000072
Gene ID33
SpeciesHomo sapiens (Human)
Gene Nameacyl-CoA dehydrogenase, long chain
Gene SymbolACADL
SynonymsACAD4; LCAD
Alternate nameslong-chain specific acyl-CoA dehydrogenase, mitochondrial; acyl-Coenzyme A dehydrogenase, long chain
Chromosome2
Map Location2q34
EC Number1.3.8.8
SummaryThe protein encoded by this gene belongs to the acyl-CoA dehydrogenase family, which is a family of mitochondrial flavoenzymes involved in fatty acid and branched chain amino-acid metabolism. This protein is one of the four enzymes that catalyze the initial step of mitochondrial beta-oxidation of straight-chain fatty acid. Defects in this gene are the cause of long-chain acyl-CoA dehydrogenase (LCAD) deficiency, leading to nonketotic hypoglycemia. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for ACADL

Proteins

long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor
Refseq ID:NP_001599
Protein GI:4501857
UniProt ID:P28330
mRNA ID:NM_001608
Length:430
RefSeq Status:REVIEWED
MAARLLRGSLRVLGGHRAPRQLPAARCSHSGGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLG
VNIAEHLGGIGGDLYSAAIVWEEQAYSNCSGPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGS
KVFISNGSLSDVVIVVAVTNHEAPSPAHGISLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAI
SASEFMFEETRNYVKQRKAFGKTVAHLQTVQHKLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAK
AYVDARVQPIYGGTNEIMKELIAREIVFDK
 
transit_peptide: 1..30
calculated_mol_wt: 3239
peptide sequence: 
MAARLLRGSLRVLGGHRAPRQLPAARCSHS

mat_peptide: 31..430
product: long-chain specific acyl-CoA dehydrogenase, mitochondrial
calculated_mol_wt: 44435
peptide sequence: 
GGEERLETPSAKKLTDIGIRRIFSPEHDIFRKSVRKFFQEEVIPHHSEWEKAGEVSREVWEKAGKQGLLGVNIAEHLGGIGGDLYSAAIVWEEQAYSNCS
GPGFSIHSGIVMSYITNHGSEEQIKHFIPQMTAGKCIGAIAMTEPGAGSDLQGIKTNAKKDGSDWILNGSKVFISNGSLSDVVIVVAVTNHEAPSPAHGI
SLFLVENGMKGFIKGRKLHKMGLKAQDTAELFFEDIRLPASALLGEENKGFYYIMKELPQERLLIADVAISASEFMFEETRNYVKQRKAFGKTVAHLQTV
QHKLAELKTHICVTRAFVDNCLQLHEAKRLDSATACMAKYWASELQNSVAYDCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIAREIVFDK