LMPD Database

LMP000054

UniProt Annotations

Entry Information
Gene Namesterol O-acyltransferase 1
Protein EntrySOAT1_HUMAN
UniProt IDP35610
SpeciesHuman
Comments
Comment typeDescription
Alternative ProductsEvent=Alternative splicing; Named isoforms=3; Name=1; IsoId=P35610-1; Sequence=Displayed; Name=2; IsoId=P35610-2; Sequence=VSP_045331; Name=3; IsoId=P35610-3; Sequence=VSP_045330;
Catalytic ActivityAcyl-CoA + cholesterol = CoA + cholesterol ester.
FunctionCatalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.
InductionHighly activated by the presence of cholesterol.
InteractionQ9Y5Z9:UBIAD1; NbExp=3; IntAct=EBI-6621997, EBI-2819725;
SimilarityBelongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Subcellular LocationEndoplasmic reticulum membrane ; Multi-pass membrane protein .
SubunitMay form homo- or heterodimers. Interacts with UBIAD1.