Research library - browse by date

This library is a growing collection of the most significant research advances and key review articles, categorized by subject areas, from across the literature.

  • January 2012

    • Triggering Actin Comets Versus Membrane Ruffles: Distinctive Effects of Phosphoinositides on Actin Reorganization

      Ueno T., Falkenburger B.H., Pohlmeyer C. and Inoue T.

      Science Signaling 4, ra87 (2011)

      [doi: 10.1126/scisignal.2002033]

    • M2 macrophages exhibit higher sensitivity to oxLDL-induced lipotoxicity than other monocyte/macrophage subtypes

      Isa S., Ruffino J., Ahluwalia M., Thomas A., Morris K. et al.

      Lipids in Health and Disease 10, (2011)

      [doi: 10.1186/1476-511X-10-229]

    • Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2

      Mahankali M., Peng H., Henkels K., Dinauer M. and Gomez-Cambronero J.

      Proceedings of the National Academy of Sciences 108, (2011)

      [doi: 10.1073/pnas.1114692108]

    • Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers

      de Saint-Jean M., Delfosse V., Douguet D., Chicanne G., Payrastre B. et al.

      The Journal of Cell Biology 195, (2011)

      [doi: 10.1083/jcb.201104062]

    • Emerging roles for retinoids in regeneration and differentiation in normal and disease states

      Gudas L.

      Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1821, (2012)

      [doi: 10.1016/j.bbalip.2011.08.002]

    • Signaling by vitamin A and retinol-binding protein in regulation of insulin responses and lipid homeostasis

      Berrya D. and Noy N.

      Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1821, (2012)

      [doi: 10.1016/j.bbalip.2011.07.002]

    • Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice

      Zhao J., Zhao J., Legge K. and Perlman S.

      The Journal of Clinical Investigation 121, (2011)

      [doi: 10.1172/JCI59777]

    • In vivo visualization and attenuation of oxidized lipid accumulation in hypercholesterolemic zebrafish

      Fang L., Green S., Baek J., Lee S., Ellett F. et al.

      The Journal of Clinical Investigation 121, (2011)

      [doi: 10.1172/JCI57755]

    • Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1

      Garofalo K., Penno A., Schmidt B., Lee H., Frosch M. et al.

      The Journal of Clinical Investigation 121, (2011)

      [doi: 10.1172/JCI57549]

    • Ceramide Kinase Regulates the Production of Tumor Necrosis Factor α (TNFα) via Inhibition of TNFα-converting Enzyme

      Lamour N., Wijesinghe D., Mietla J., Ward K., Stahelin R. et al.

      Journal of Biological Chemistry 286, (2011)

      [doi: 10.1074/jbc.M111.310169]

    • WNK1 Promotes PIP2 Synthesis to Coordinate Growth Factor and GPCR-Gq Signaling

      An S., Cha S., Yoon J., Chang S., Ross E. et al.

      Current Biology 21, (2011)

      [doi: 10.1016/j.cub.2011.11.002]

    • TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

      Pols T., Nomura M., Harach T., lo Sasso G., Oosterveer M. et al.

      Cell Metabolism 14, (2011)

      [doi: 10.1016/j.cmet.2011.11.006]

    • Choline metabolism in malignant transformation

      Glunde K., Bhujwalla Z. and Ronen S.

      Nat Rev Cancer 11, 835 - 848 (2011)

      [doi: 10.1038/nrc3162]

    • Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

      Metallo C., Gameiro P., Bell E., Mattaini K., Yang J. et al.

      Nature (Published online 20 November 2011)

      [doi: 10.1038/nature10602]

    • Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

      Nieto-Posadas A., Picazo-Juárez G., Llorente I., Jara-Oseguera A., Morales-Lázaro S. et al.

      Nat Chem Biol (Published online 20 November 2011)

      [doi: 10.1038/nchembio.712]

    • Phosphatidylserine promotes polar Cdc42 localization

      Freisinger T. and Wedlich-Soldner R.

      Nat Cell Biol 13, 1387 - 1388 (2011)

      [doi: 10.1038/ncb2382]

    • Fatty Acids Suppress Autophagic Turnover in β-Cells

      Las G., Serada S., Wikstrom J., Twig G. and Shirihai O.

      Journal of Biological Chemistry 286, (2011)

      [doi: 10.1074/jbc.M111.242412]

    • LRP6 regulates LDLR-mediated LDL uptake

      Ye Z., Go G., Singh R., Liu W., Keramati A. et al.

      Journal of Biological Chemistry (Published online 28 November 2011)

      [doi: 10.1074/jbc.M111.295287]

    • Phosphatidylserine Binding Is Essential for Plasma Membrane Recruitment and Signaling Function of 3-Phosphoinositide-dependent Kinase-1

      Lucas N. and Cho W.

      Journal of Biological Chemistry 286, (2011)

      [doi: 10.1074/jbc.M111.300806]

    • Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecule Inhibitors for the Treatment of Metabolic Diseases

      Cao J., Zhou Y., Peng H., Huang X., Stahler S. et al.

      Journal of Biological Chemistry 286, (2011)

      [doi: 10.1074/jbc.M111.245456]

    • A Glycosphingolipid/Caveolin-1 Signaling Complex Inhibits Motility of Human Ovarian Carcinoma Cells

      Prinetti A., Cao T., Illuzzi G., Prioni S., Aureli M. et al.

      Journal of Biological Chemistry 286, (2011)

      [doi: 10.1074/jbc.M111.286146]

    • Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy

      Barcelo-Coblijn G., Martin M., de Almeida R., Noguera-Salva M., Marcilla-Etxenike A. et al.

      Proceedings of the National Academy of Sciences 108, (2011)

      [doi: 10.1073/pnas.1115484108]

    • Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma

      Murata T., Aritake K., Matsumoto S., Kamauchi S., Nakagawa T. et al.

      Proceedings of the National Academy of Sciences (Published online 6 December 2011)

      [doi: 10.1073/pnas.1110011108]

    • FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors

      Calkin A., Goult B., Zhang L., Fairall L., Hong C. et al.

      Proceedings of the National Academy of Sciences (Published online 13 December 2011)

      [doi: 10.1073/pnas.1111589108]

    • Estrogen receptor β and 17β-hydroxysteroid dehydrogenase type 6, a growth regulatory pathway that is lost in prostate cancer

      Muthusamy S., Andersson S., Kim H., Butler R., Waage L. et al.

      Proceedings of the National Academy of Sciences of the United States of America 108, (2011)

      [doi: 10.1073/pnas.1117772108]

    • A Highly Dynamic ER-Derived Phosphatidylinositol-Synthesizing Organelle Supplies Phosphoinositides to Cellular Membranes

      Kim Y., Guzman-Hernandez M. and Balla T.

      Developmental Cell 21, (2011)

      [doi: 10.1016/j.devcel.2011.09.005]

    • Phosphoinositide Function in Cytokinesis

      Brill J., Wong R. and Wilde A.

      Current Biology 21, (2011)

      [doi: 10.1016/j.cub.2011.10.001]

    • Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5)2 synthesis

      Legate K., Takahashi S., Bonakdar N., Fabry B., Boettiger D. et al.

      EMBO J (Published online 16 September 2011)

      [doi: 10.1038/emboj.2011.332]

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