Research library - browse by date

This library is a growing collection of the most significant research advances and key review articles, categorized by subject areas, from across the literature.

  • January 2011

    • Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain

      Anutosh Chakraborty et al.

      Cell 143, 897-910 (2010)

      [doi: 10.1016/j.cell.2010.11.032]

    • Lipid Trafficking sans Vesicles: Where, Why, How?

      William A. Prinz

      Cell 143, 870-874 (2010)

      [doi: 10.1016/j.cell.2010.11.031]

    • Membrane Budding

      James H. Hurley, Evzen Boura, Lars-Anders Carlson & Bartosz Różycki

      Cell 143, 875-887 (2010)

      [doi: 10.1016/j.cell.2010.11.030]

    • Lipidomics: New Tools and Applications

      Markus R. Wenk

      Cell 143, 888-895 (2010)

      [doi: 10.1016/j.cell.2010.11.033]

    • Lipid signalling in pathogenic fungi

      Arpita Singh & Maurizio Del poeta

      Cellular Microbiology (Published online 5 December 2010)

      [doi: 10.1111/j.1462-5822.2010.01550.x]

    • The Palmitoylation Two-step: Mutational Analysis of Saccharomyces cerevisiae Erf2 Reveals a Two-step Reaction Mechanism for Protein Palmitoylation by DHHC Enzymes

      Journal of Biological Chemistry 285, 38104–38114 (2010)

      [doi: 10.1074/jbc.P110.169102]

    • Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

      C. G. Fedele et al.

      Proceedings of the National Academy of Sciences (Published online 2 December 2010)

      [doi: 10.1073/pnas.1015245107]

    • Protease-Activated Receptor Signaling in Platelets Activates Cytosolic Phospholipase A2 Differently for Cyclooxygenase-1 and 12-Lipoxygenase Catalysis

      M. Holinstat et al.

      Arteriosclerosis, Thrombosis, and Vascular Biology (Published online 2 December 2010)

      [doi: 10.1161/ATVBAHA.110.219527]

    • New insights into the formation of fungal aromatic polyketides

      Jason M. Crawford & Craig A. Townsend

      Nature Reviews Microbiology 8, 879-889 (2010)

      [doi: 10.1038/nrmicro2465]

    • Diabetes and Insulin in Regulation of Brain Cholesterol Metabolism

      Ryo Suzuki et al.

      Cell Metabolism 12, 567-579 (2010)

      [doi: 10.1016/j.cmet.2010.11.006]

    • Class IA Phosphatidylinositol 3-Kinase in Pancreatic β Cells Controls Insulin Secretion by Multiple Mechanisms

      Kazuma Kaneko et al.

      Cell Metabolism 12, 619-632 (2010)

      [doi: 10.1016/j.cmet.2010.11.005]

    • Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

      Ichiro Onoyama et al.

      Journal of Clinical Investigation (Published online 1 December 2010)

      [doi: 10.1172/JCI40725]

    • Vitamin D, disease and therapeutic opportunities

      Lori A. Plum & Hector F. Deluca

      Nature Reviews Drug Discovery 9, 941-955 (2010)

      [doi: 10.1038/nrd3318]

    • Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice

      Ralph Burkhardt et al.

      Journal of Clinical Investigation 120, 4410–4414 (2010)

      [doi: 10.1172/JCI44213]

    • Synergic effect of Eicosapentaenoic acid and Lovastatin on gene expression of HMGCoA reductase and LDL receptor in cultured HepG2 cells

      Maria Notarnicola et al.

      Lipids in Health and Disease 9, 135-143 (2010)

      [doi: 10.1186/1476-511X-9-135]

    • Requirement for Golgi-localized PI(4)P in fusion of COPII vesicles with Golgi compartments

      A. Lorente-rodriguez & C. Barlowe

      Molecular Biology of the Cell (Published online 30 November 2010)

      [doi: 10.1091/mbc.E10-04-0317]

    • Transgenic conversion of omega-6 into omega-3 fatty acids in a mouse model of Parkinson's disease

      M. Bousquet et al.

      The Journal of Lipid Research (Published online 29 November 2010)

      [doi: 10.1194/jlr.M011692]

    • Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis

      J. N. Lee et al.

      Proceedings of the National Academy of Sciences 107, 21424-21429 (2010)

      [doi: 10.1073/pnas.1011859107]

    • Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells

      Y. H. Bae et al.

      Proceedings of the National Academy of Sciences 107, 21547-21552 (2010)

      [doi: 10.1073/pnas.1002309107]

    • Identification of 9-cis-retinoic acid as a pancreas-specific autacoid that attenuates glucose-stimulated insulin secretion

      M. A. Kane et al.

      Proceedings of the National Academy of Sciences 107, 21884-21889 (2010)

      [doi: 10.1073/pnas.1008859107]

    • 14S,21R-dihydroxy Docosahexaenoic Acid Remedies Impaired Healing and Mesenchymal Stem Cell Functions in Diabetic Wounds

      H. Tian, Y. Lu, S. P. Shah & S. Hong

      Journal of Biological Chemistry (Published online 26 November 2010)

      [doi: 10.1074/jbc.M110.100388]

    • An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production

      K. Mathurin et al.

      Journal of Biological Chemistry (Published online 26 November 2010)

      [doi: 10.1074/jbc.M110.178277]

    • Calcium-dependent phospholipid scrambling by TMEM16F

      Jun Suzuki et al.

      Nature 468, 834–838 (2010)

      [doi: 10.1038/nature09583]

    • Structure and control of the actin regulatory WAVE complex

      Zhucheng Chen et al.

      Nature 468, 533–538 (2010)

      [doi: 10.1038/nature09623]

    • Ht31, a PKA anchoring inhibitor, induces robust cholesterol efflux and reverses macrophage foam cell formation through ABCA1

      L. Ma et al.

      Journal of Biological Chemistry (Published online 24 November 2010)

      [doi: 10.1074/jbc.M110.173666]

    • Inhibitor of Fatty Acid Amide Hydrolase Normalizes Cardiovascular Function in Hypertension without Adverse Metabolic Effects

      Grzegorz Godlewski et al.

      Chemistry & Biology 17, 1256-1266 (2010)

      [doi: 10.1016/j.chembiol.2010.08.013]

    • Enzyme assays: Detection by failure

      Nicholas A. Melosh

      Nature Chemistry 2, 1006–1007 (2010)

      [doi: 10.1038/nchem.914]

    • De Novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation

      X. Wei et al.

      Journal of Biological Chemistry (Published online 23 November 2010)

      [doi: 10.1074/jbc.M110.193037]

    • Phosphatidylinositol 3-Kinase Activation Attenuates the TLR2-Mediated Macrophage Proinflammatory Cytokine Response to Francisella tularensis Live Vaccine Strain

      E. A. Medina, I. R. Morris & M. T. Berton

      The Journal of Immunology 185, 7562-7572 (2010)

      [doi: 10.4049/jimmunol.0903790]

    • A novel mechanism of lysosomal acid sphingomyelinase maturation - requirement for carboxy-terminal proteolytic processing

      R. W. Jenkins et al.

      Journal of Biological Chemistry (Published online 22 November 2010)

      [doi: 10.1074/jbc.M110.155234]

    • STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

      Heehyoung Lee et al.

      Nature Medicine (Published online 21 November 2010)

      [doi: 10.1038/nm.2250]

    • The MARCKS protein plays a critical role in PIP2 metabolism and directed cell movement in vascular endothelial cells

      H. Kalwa & T. Michel

      Journal of Biological Chemistry (Published online 20 November 2010)

      [doi: 10.1074/jbc.M110.196022]

    • An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase

      J. Z. Long, M. La cava, X. Jin & B. F. Cravatt

      The Journal of Lipid Research (Published online 19 November 2010)

      [doi: 10.1194/jlr.M012153]

    • The sphingosine 1-phosphate transporter, SPNS2, functions as a transporter of the phosphorylated form of the immunomodulating agent FTY720.

      Y. Hisano et al.

      Journal of Biological Chemistry (Published online 17 November 2010)

      [doi: 10.1074/jbc.M110.171116]

    • Characterisation of a binding site for anionic phospholipids on KCNQ1

      A. M. Thomas, S. C. Harmer, T. Khambra & A. Tinker

      Journal of Biological Chemistry (Published online 17 November 2010)

      [doi: 10.1074/jbc.M110.153551]

    • Mitochondrially targeted ceramide preferentially promotes autophagy, retards cell growth, and induces apoptosis

      Q. Hou et al.

      The Journal of Lipid Research (Published online 16 November 2010)

      [doi: 10.1194/jlr.M012161]

    • Unsaturated fatty acids prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages.

      J. Ishiyama et al.

      The Journal of Lipid Research (Published online 15 November 2010)

      [doi: 10.1194/jlr.M007104]

    • p53-mediated apoptosis requires inositol hexakisphosphate kinase-2

      M. A. Koldobskiy et al.

      Proceedings of the National Academy of Sciences 107, 20947-20951 (2010)

      [doi: 10.1073/pnas.1015671107]

    • Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm

      A. Di gennaro et al.

      Proceedings of the National Academy of Sciences 107, 21093-21097 (2010)

      [doi: 10.1073/pnas.1015166107]

    • Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens

      Brad A Grueter, Gabor Brasnjo & Robert C Malenka

      Nature Neuroscience 13, 1519–1525 (2010)

      [doi: 10.1038/nn.2685]

    • Oxidized Phospholipids Are More Potent Antagonists of Lipopolysaccharide than Inducers of Inflammation

      O. V. Oskolkova et al.

      The Journal of Immunology 185, 7706-7712 (2010)

      [doi: 10.4049/jimmunol.0903594]

    • Circulating sphingolipid biomarkers in models of type 1 diabetes

      T. E. Fox et al.

      The Journal of Lipid Research (Published online 10 November 2010)

      [doi: 10.1194/jlr.M010595]

    • The specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analysed in vivo

      C. J. Pynn et al.

      The Journal of Lipid Research (Published online 10 November 2010)

      [doi: 10.1194/jlr.D011916]

    • Biochemical Studies on Sphingolipids of Artemia franciscana (II): Novel Neutral Glycosphingolipids

      H. Kojima et al.

      The Journal of Lipid Research (Published online 9 November 2010)

      [doi: 10.1194/jlr.M010173]

    • A novel fluorogenic substrate for the measurement of endothelial lipase activity

      A. L. Darrow et al.

      The Journal of Lipid Research (Published online 9 November 2010)

      [doi: 10.1194/jlr.D007971]

    • Mutual modulation between membrane-embedded receptor clustering and ligand binding in lipid membranes

      Salvador Tomas & Lilia Milanesi

      Nature Chemistry 2, 1077–1083 (2010)

      [doi: 10.1038/nchem.892]

    • Atherogenic Lipids and Lipoproteins Trigger CD36-TLR2-Dependent Apoptosis in Macrophages Undergoing Endoplasmic Reticulum Stress

      Tracie A. Seimon et al.

      Cell Metabolism 12, 467-482 (2010)

      [doi: 10.1016/j.cmet.2010.09.010] LIPID MAPS

    • Ceramide and Ceramide 1-Phosphate Are Negative Regulators of TNF- Production Induced by Lipopolysaccharide

      S. Jozefowski et al.

      The Journal of Immunology 185, 6960-6973 (2010)

      [doi: 10.4049/jimmunol.0902926]

    • Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

      Fei Wang et al.

      Journal of Clinical Investigation 120, 3979–3995 (2010)

      [doi: 10.1172/JCI42315]

    • Transbilayer organization of membrane cholesterol at low concentrations: Implications in health and disease

      Arunima Chaudhuri & Amitabha Chattopadhyay

      Biochimica et Biophysica Acta (BBA) - Biomembranes 1808, 19-25 (2010)

      [doi: 10.1016/j.bbamem.2010.10.013] LIPID MAPS

    • A biochemical mechanism for the oncogenic potential of the p110 catalytic subunit of phosphoinositide 3-kinase

      H. A. Dbouk, H. Pang, A. Fiser & J. M. Backer

      Proceedings of the National Academy of Sciences 107, 19897-19902 (2010)

      [doi: 10.1073/pnas.1008739107]

    • Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway

      B. Sarmah & S. R. Wente

      Proceedings of the National Academy of Sciences 107, 19921-19926 (2010)

      [doi: 10.1073/pnas.1007256107]

    • Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: Involvement of the bioactive sphingolipid ceramide

      X. Zou et al.

      Journal of Biological Chemistry (Published online 25 October 2010)

      [doi: 10.1074/jbc.M110.127837]

    • Vitamin D Suppresses Th17 Cytokine Production by Inducing C/EBP Homologous Protein (CHOP) Expression

      S. H. Chang, Y. Chung & C. Dong

      Journal of Biological Chemistry 285, 38751-38755 (2010)

      [doi: 10.1074/jbc.C110.185777]

    • Membranes in Balance: Mechanisms of Sphingolipid Homeostasis

      David K. Breslow & Jonathan S. Weissman

      Molecular Cell 40, 267-279 (2010)

      [doi: 10.1016/j.molcel.2010.10.005]

    • Small-molecule inactivation of HIV-1 NCp7 by repetitive intracellular acyl transfer

      Lisa M Miller Jenkins et al.

      Nature Chemical Biology 6, 887–889 (2010)

      [doi: 10.1038/nchembio.456]

    • Distinct glycan-charged phosphodolichol carriers are required for the assembly of the pentasaccharide N-linked to the Haloferax volcanii S-layer glycoprotein

      Ziqiang Guan et al.

      Molecular Microbiology 78, 1294–1303 (2010)

      [doi: 10.1111/j.1365-2958.2010.07405.x] LIPID MAPS

    • The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells

      C. Loveridge et al.

      Journal of Biological Chemistry 285, 38841-38852 (2010)

      [doi: 10.1074/jbc.M110.127993]

    • Unexpected Expression Pattern for Glycosylphosphatidylinositol-anchored HDL-binding Protein 1 (GPIHBP1) in Mouse Tissues Revealed by Positron Emission Tomography Scanning

      T. Olafsen et al.

      Journal of Biological Chemistry 285, 39239-39248 (2010)

      [doi: 10.1074/jbc.M110.171041]

    • Oxysterol Binding Protein-dependent Activation of Sphingomyelin Synthesis in the Golgi Apparatus Requires Phosphatidylinositol 4-Kinase II

      S. Banerji et al.

      Molecular Biology of the Cell 21, 4141-4150 (2010)

      [doi: 10.1091/mbc.E10-05-0424]

    • Topological Orientation of Acyl-CoA:Diacylglycerol Acyltransferase-1 (DGAT1) and Identification of a Putative Active Site Histidine and the Role of the N Terminus in Dimer/Tetramer Formation

      P. J. Mcfie, S. L. Stone, S. L. Banman & S. J. Stone

      Journal of Biological Chemistry 285, 37377-37387 (2010)

      [doi: 10.1074/jbc.M110.163691]

    • Relationship between MALDI IMS Intensity and Measured Quantity of Selected Phospholipids in Rat Brain Sections

      Joseph A. Hankin & Robert C. Murphy

      Analytical Chemistry 82, 8476–8484 (2010)

      [doi: 10.1021/ac101079v] LIPID MAPS

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