Lipidomics update - August 2010
The lipidomics update provides an overview of developments in lipid research. Each month we offer a fresh collection of research, news and events for the specialist and the interested non-specialist alike. Register for our email alert to stay informed.
Lipid of the month
Sphingosine-1-phosphate
Essential for mammalian development, this bioactive, oncogenic lipid signals through cell-surface receptors and emerging intracellular interactions.
Research highlights
Sphingosine-1-phosphate: Internal protectionS1P suppresses apoptosis by binding the E3 ubiquitin ligase TRAF2, independently of cell surface receptors.
Membrane trafficking: PIP2 calcium let-out causeDirect activation of TRPML channels by PI(3,5)P2 controls Ca2+ release and membrane fusion and fission events.
Cardiovascular disorders: MicroRNA modulation of cholesterolEpigenetic regulation of cholesterol homeostasis by miR-33 might be a target for cardiovascular disorders.
Inflammation: Hope for sepsis treatmentBlockade of sphingosine kinase 1 protects mice from lethal inflammation induced by bacteria.
News
- US charges scientist with economic espionage
- Protein mapping gains a human focus
- DNA factory builds up steam
- Ageing cells lose protein pumps
- Marmots fatten up on climate change
- Diabetes drugs offered fresh start
Events calendar
Research library
- Subcellular organelle lipidomics in TLR 4-activated macrophages The Journal of Lipid Research
- A plasma-membrane E-MAP reveals links of the eisosome with sphingolipid metabolism and endosomal trafficking Nature Structural & Molecular Biology
- more from the research library
