Lipidomics update - December 2009
The lipidomics update provides an overview of developments in lipid research. Each month we offer a fresh collection of research, news and events for the specialist and the interested non-specialist alike. Register for our email alert to stay informed.
Lipid of the month
Phosphatidylinositol-4-phosphate
The precisely regulated metabolism of PI(4)P, the most abundant monophosphorylated inositol phospholipid of mammalian cells, controls essential trafficking processes.
Research highlights
Golgi vesicle formation: Flipping coincidenceGolgi flippase activity and transport vesicle budding are regulated by coincident binding of phosphatidylinositol-4-phosphate and an ArfGEF to the Saccharomyces cerevisiae ATPase Drs2p.
C. elegans fat stores: Misled by Nile redDyes commonly used to assess fat storage in Caenorhabditis elegans do not stain major triglyceride stores or provide an accurate readout for lipid metabolism in genomic screens.
Metabolic disease: Dual benefit of bile acid receptor agonistA synthetic bile acid receptor agonist improves glucose tolerance, attenuates diet-induced weight gain, and might be a new treatment for metabolic disorders.
Natural killer T cells: Switching on human NKT cellsLysophosphatidylcholine is a self antigen for human natural killer T cells.
News
- Plant genetics database at risk as funds run dry
- How the sponge stays slim
- New targets for old drugs
- Biologists rally to sequence 'neglected' microbes
- Swine flu: One killer virus, three key questions
Events calendar
3 - 4 May 2010
20 - 25 June, 2010
Research library
- Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo Proceedings of the National Academy of Sciences
- Single embryo and oocyte lipid fingerprinting by mass spectrometry The Journal of Lipid Research
- more from the research library
