Lipidomics update - September 2009
The lipidomics update provides an overview of developments in lipid research. Each month we offer a fresh collection of research, news and events for the specialist and the interested non-specialist alike. Register for our email alert to stay informed.
Lipid of the month
Trichostatin A
Initially isolated from bacteria as an antifungal antibiotic, the linear polyketide Trichostatin A is a potent reversible inhibitor of histone deacetylases, with myriad applications.
Research highlights
Alzheimer's and oxidized cholesterol: Neighbors come togetherAn oxidized form of cholesterol alters membrane organization and might disrupt cellular function in Alzheimer's disease.
Lipids and Golgi function: An acyltransferase stops trafficA lysophosphatidic acid-specific acyltransferase enzyme regulates Golgi morphology and function.
Inflammation: Finding the T in fatThe microenvironment in obese adipose tissue deregulates T cell responses.
Hepatocellular carcinoma: Visceral fat is a risk factor for nonviral, nonalcoholic HCC recurrenceFat accumulation around internal organs predicts recurrence of hepatocellular carcinoma.
Prevention: Lowering cholesterol in statin-intolerant patientsLDL-cholesterol is effectively reduced by a herbal supplement in patients with statin-associated myalgia.
News
- Seed money available for research into Barth syndrome
- Cardiovascular disease gets personal
- Return of the rat
- Collins sets out his vision for the NIH
Events calendar
Crystallization of Lipids, Nucleation to Application
3 - 4 October 2009
24 - 29 January 2010
Research library
- Mycobacterium tuberculosis WhiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response. PLoS Pathogens
- Large D/H variations in bacterial lipids reflect central metabolic pathways. Proceedings of the National Academy of Sciences
- more from the research library
