Lipidomics update - August 2009

Lipid of the month

N-arachidonoyl glycine
Lipoamino acids have emerged from the identification of obscure prokaryotic molecules, through pharmacologically active synthetic compounds, to endogenous mammalian signaling molecules. N-arachidonoyl glycine (NAGly), the best-characterized acyl amino acid, has pain-relieving properties.

Research highlights

• Targeted lipidomics: Planned discovery

  A targeted lipidomic strategy allows rapid and sensitive identification of a novel family of mammalian acyl amino acids.

• Macrophage lipid droplets: Inert? Eicosa' not!

  Lipid droplets are sites of eicosanoid production, implicated in atherosclerosis.

• Sphingosine 1-phosphate signaling: T_reg or not T_reg, that is the question

  S1P1 activates the mTOR-Akt pathway to suppress T_reg-cell differentiation and activity.

• Lipid metabolism: An 'IDOL' regulator of blood cholesterol levels

  Liver X receptor regulates IDOL expression, induces degradation of low-density lipoprotein receptor, and controls cholesterol homeostasis.

Events calendar

• Obesity management for medical professionals

  2 - 5 August 2009

• 50th International Conference on the Bioscience of Lipids: Biological and regulatory functions of lipid molecular species

  1 - 5 September 2009

more events