LMPD Database

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LMP006744

Record overview

LMPD IDLMP006744
Gene ID23761
SpeciesHomo sapiens (Human)
Gene Namephosphatidylserine decarboxylase
Gene SymbolPISD
SynonymsDJ858B16; PSD; PSDC; PSSC; dJ858B16.2
Alternate namesphosphatidylserine decarboxylase proenzyme
Chromosome22
Map Location22q12.2
EC Number4.1.1.65
SummaryPhosphatidylserine decarboxylases (PSDs; EC 4.1.1.65) catalyze the formation of phosphatidylethanolamine (PE) by decarboxylation of phosphatidylserine (PS). Type I PSDs, such as PISD, are targeted to the inner mitochondrial membrane by an N-terminal targeting sequence. PISD also contains a conserved LGST motif that functions as an autocatalytic cleavage site where the proenzyme is split into mature alpha and beta subunits (Schuiki and Daum, 2009 [PubMed 19165886]).[supplied by OMIM, Jul 2010]
OrthologsView orthologs and multiple alignments for PISD

Proteins

phosphatidylserine decarboxylase proenzyme
Refseq ID:NP_055153
Protein GI:13489112
UniProt ID:Q9UG56
mRNA ID:NM_014338
Length:375
RefSeq Status:VALIDATED
MMCQSEARQGPELRAAKWLHFPQLALRRRLGQLSCMSRPALKLRSWPLTVLYYLLPFGALRPLSRVGWRPVSRVALYKSVPTRLLSRAWGRLNQVELPHW
LRRPVYSLYIWTFGVNMKEAAVEDLHHYRNLSEFFRRKLKPQARPVCGLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMCTEDLPFPPAA
SCDSFKNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFD
RDLHTNSPRHSKGSYNDFSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEAPKDFNFQLKTGQKIRFGEALGSL