LMPD Database

New search | Record Overview | Ontology/Pathway Information | Domain Information | UniProt Annotations | Related Proteins
LMP002479

Record overview

LMPD IDLMP002479
Gene ID4056
SpeciesHomo sapiens (Human)
Gene Nameleukotriene C4 synthase
Gene SymbolLTC4S
Synonyms-
Alternate namesleukotriene C4 synthase; LTC4 synthase
Chromosome5
Map Location5q35
EC Number4.4.1.20
SummaryThe MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]
OrthologsView orthologs and multiple alignments for LTC4S

Proteins

leukotriene C4 synthase
Refseq ID:NP_665874
Protein GI:22035629
UniProt ID:Q16873
mRNA ID:NM_145867
Length:150
RefSeq Status:REVIEWED
MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARS
AQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRTLLPWA