LMPD Database

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LMP001795

Record overview

LMPD IDLMP001795
Gene ID81579
SpeciesHomo sapiens (Human)
Gene Namephospholipase A2, group XIIA
Gene SymbolPLA2G12A
SynonymsGXII; PLA2G12; ROSSY
Chromosome4
Map Location4q25
SummarySecreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 [PubMed 11031251]).[supplied by OMIM, Mar 2008]
OrthologsView orthologs and multiple alignments for PLA2G12A

Proteins

group XIIA secretory phospholipase A2 precursor
Refseq ID:NP_110448
Protein GI:21361944
UniProt ID:Q542Y6
mRNA ID:NM_030821
Length:189
RefSeq Status:VALIDATED
MALLSRPALTLLLLLMAAVVRCQEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGI
PSLTKCCNQHDRCYETCGKSKNDCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACRCHYEEKTDL
 
sig_peptide: 1..22
inference: COORDINATES: ab initio prediction:SignalP:4.0
calculated_mol_wt: 2369
peptide sequence: 
MALLSRPALTLLLLLMAAVVRC

mat_peptide: 23..189
product: Group XIIA secretory phospholipase A2
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (Q9BZM1.1)
calculated_mol_wt: 18716
peptide sequence: 
QEQAQTTDWRATLKTIRNGVHKIDTYLNAALDLLGGEDGLCQYKCSDGSKPFPRYGYKPSPPNGCGSPLFGVHLNIGIPSLTKCCNQHDRCYETCGKSKN
DCDEEFQYCLSKICRDVQKTLGLTQHVQACETTVELLFDSVIHLGCKPYLDSQRAACRCHYEEKTDL