LMPD Database

LMP001635

Record overview

LMPD IDLMP001635
Gene ID2678
SpeciesHomo sapiens (Human)
Gene Namegamma-glutamyltransferase 1
Gene SymbolGGT1
SynonymsCD224; D22S672; D22S732; GGT; GGT 1; GTG
Alternate namesgamma-glutamyltranspeptidase 1; glutathione hydrolase 1; leukotriene-C4 hydrolase
Chromosome22
Map Location22q11.23
EC Number2.3.2.2
SummaryThe enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014]
OrthologsView orthologs and multiple alignments for GGT1

Proteins

gamma-glutamyltranspeptidase 1 precursor
Refseq ID:NP_001275762
Protein GI:572152963
UniProt ID:P19440
mRNA ID:NM_001288833
Length:569
RefSeq Status:REVIEWED
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRK
AEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRK
VLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTI
NLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTATALAIIYNLWFGYDVKRAVE
EPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY
 
gamma-glutamyltranspeptidase 1 precursor
Refseq ID:NP_038265
Protein GI:572153074
UniProt ID:P19440
mRNA ID:NM_013421
Length:569
RefSeq Status:REVIEWED
Protein sequence is identical to GI:572152963 (mRNA isoform)
 
gamma-glutamyltranspeptidase 1 precursor
Refseq ID:NP_038347
Protein GI:73915092
UniProt ID:P19440
mRNA ID:NM_013430
Length:569
RefSeq Status:REVIEWED
Protein sequence is identical to GI:572152963 (mRNA isoform)
 
mat_peptide: 1..380
product: Gamma-glutamyltranspeptidase 1 heavy chain
experiment: experimental evidence, no additional details recorded
note: propagated from UniProtKB/Swiss-Prot (P19440.2)
calculated_mol_wt: 41431
peptide sequence: 
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRK
AEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRK
VLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG mat_peptide: 381..569 product: Gamma-glutamyltranspeptidase 1 light chain experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P19440.2) calculated_mol_wt: 19998 peptide sequence: TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY mat_peptide: 1..380 product: Gamma-glutamyltranspeptidase 1 heavy chain experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P19440.2) calculated_mol_wt: 41431 peptide sequence: MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRK
AEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRK
VLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG mat_peptide: 381..569 product: Gamma-glutamyltranspeptidase 1 light chain experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P19440.2) calculated_mol_wt: 19998 peptide sequence: TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY mat_peptide: 1..380 product: Gamma-glutamyltranspeptidase 1 heavy chain experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P19440.2) calculated_mol_wt: 41431 peptide sequence: MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAVAADAKQCSKIGRDALRDGGSAVDAAIAALLCVGLMNAHSMGIGGGLFLTIYNSTTRK
AEVINAREVAPRLAFATMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAALENKRTVIEQQPVLCEVFCRDRK
VLREGERLTLPQLADTYETLAIEGAQAFYNGSLTAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDVVLYMPSAPLSGPVLALILNILKGYNFSR
ESVESPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRAQISDDTTHPISYYKPEFYTPDDGG mat_peptide: 381..569 product: Gamma-glutamyltranspeptidase 1 light chain experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P19440.2) calculated_mol_wt: 19998 peptide sequence: TAHLSVVAEDGSAVSATSTINLYFGSKVRSPVSGILFNNEMDDFSSPSITNEFGVPPSPANFIQPGKQPLSSMCPTIMVGQDGQVRMVVGAAGGTQITTA
TALAIIYNLWFGYDVKRAVEEPRLHNQLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAASDSRKGGEPAGY