| Brown, H. Alex | Vanderbilt University Medical Center | Core Director |
| Dennis, Edward | University of California, San Diego | Core/Bridge Director |
| Glass, Christopher | University of California, San Diego | Core/Bridge Director |
| Merrill, Alfred | Georgia Institute of Technology | Core Director |
| Murphy, Robert | National Jewish Medical & Research Center | Core/Bridge Director |
| Raetz, Christian | Duke University Medical Center | Core Director |
| Russell, David | UT Southwestern Medical Center | Core Director |
| Shaw, Walter | Avanti Polar Lipids, Inc. | Core Co-director |
| Subramaniam, Shankar | University of California, San Diego | Core/Bridge Director |
| VanNieuwenhze, Michael | University of California, San Diego | Core Co-Director |
| White, Stephen H. | University of California, Irvine | Core Co-director |
| Witztum, Joseph | University of California, San Diego | Bridge Director |
| Boger, Dale | Scripps Research Institute | Participating Investigator Core F(B) |
| Brown, Michael | UT Southwestern Medical Center | Participating Investigator Core J |
| Cantley, Lewis | Harvard Medical School | Participating Investigator Core H |
| Costello, Catherine | Boston University School of Medicine | Participating Investigator Core E |
| Falck, Camille | UT Southwestern Medical Center | Participating Investigator Core F(A) |
| Goldstein, Joseph | UT Southwestern Medical Center | Participating Investigator Core J |
| Hannun, Yusuf | Medical University of South Carolina | Participating Investigator Core I |
| Henson, Peter | National Jewish Medical/Research Center | Participating Investigator Core D |
| Marnett, Lawrence | Vanderbilt Institute of Chemical Biology | Participating Investigator Core G |
| Maxey, Kirk | Cayman Chemical | Participating Investigator, Core F(A) |
| Palsson, Bernhard | University of California, San Diego | Participating Investigator Bridge A |
| Poulter, Dale | University of Utah | Participating Investigator Core K |
| Roberts, Jack | Vanderbilt University Medical Center | Participating Investigator Core H |
| Serhan, Charles | Harvard Medical School | Participating Investigator Core G |
| Shipley, Graham | Boston University School of Medicine | Participating Investigator Core F(C) |
| Spiegel, Sarah | Virginia Commonwealth University | Participating Investigator Core I |
| Ulevitch, Richard | Scripps Research Institute | Participating Investigator Core K |
| Vestal, Marvin | Applied Biosystems | Participating Investigator Bridge C |
| Wooley, John | University of California, San Diego | Participating Investigator Core A |
| Yu, Robert | Medical College of Georgia | Participating Investigator Core I |
| Cartlidge, Laurie | University of California, San Diego | Administrative Coordinator, Core A |
| Deems, Raymond | University of California, San Diego | Staff Assistant, Core A |
| Garrett, Teresa | Duke University | Project Coordinator, Core K |
| Guan, Ziqiang | Duke University | Associate Research Professor, Core K |
| Hardiman, Gary | University of California, San Diego | Director, BIOGEM Microarray Core Facility, Core D |
| Hachey, David | Vanderbilt University | Investigator, Core H |
| Harkewicz, Richard | University of California, San Diego | Project Scientist, Core G |
| Milne, Steve | Vanderbilt University | Lead Scientist, Core H |
| Sullards, Cameron | Georgia Institute of Technology | Manager, Core I |
| Fernandez-Valledor, Annabel | University of California, San Diego | Investigator, Core D |
| Fahy, Eoin | University of California, San Diego | Project Coordinator, Core B,C |